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KMID : 0363620200410010107
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Journal of Korean Oriental Medicine
2020 Volume.41 No. 1 p.107 ~ p.116
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Current Status of N-of-1 Trials for Herbal Medicine -Literature Review
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Jeung Chang-Woon
Jeon Sun-Woo
Jo Hee-Geun
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Abstract
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Objectives: To overcome the limitations of randomized controlled trials, many other trials design is tested. The n-of-1 trial is a promising research method in the field of Korean medicine because of this methodology can examine the optimal treatment for each patient strictly. Therefore, we reviewed the status of N-of-1 studies on herbal medicine.
Methods: A systematic literature review was conducted based on the pubmed database. The search term were ‘N-of-1 Trial’, ‘Chinese Medicine’, ‘Herbal Medicine’, ‘Kampo’. There was no restriction in year.
Results: Four clinical trials have been identified to demonstrate the effectiveness of herbal medicines for Kidney-yin-deficiency syndrome, bronchiectasis and gastric cancer. These studies suggest that the N-of-1 design is a study that encourages patient involvement, demonstrates the effectiveness of herbal medicines and helps reduce unnecessary medication.
Conclusion: The N-of-1 clinical trial may be a rigorous methodology suitable for the clinical setting and may help the development of evidence-based Korean medicine. Attention is also needed in this research method in Korea.
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KEYWORD
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N-of-1, Single Case Studies, Clinical Trial, Herbal Medicine, Korean medicine
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